WHAT IS IT?
Desipramine (Norpramin) is a TCA antidepressant. It blocks the re-uptake of serotonin and norepinephrine.
WHEN DO WE USE IT?
Major depressive disorder: this medication is no longer a first-line therapy, however
Bulimia nervosa: antidepressants like Desipramine are effective in this condition.
Attention deficit hyperactivity disorder (ADHD): this medication is not recommended for use in children…
WHEN DO WE AVOID USING IT?
In combination with a MAOI due to the risk of serotonin syndrome.
HOW IS IT ADMINISTERED?
WHAT ARE THE SIDE EFFECTS/TOXICITY?
Anticholinergic effects: dry mouth, constipation, vision disturbances)
Cardiac effects such as conduction defects.
ANYTHING ELSE TO KEEP IN MIND?
Desipramine is the least sedating out of the TCA medications.
Page Updated: 08.12.2016