Antiviral Medications

OVERVIEW

This page organizes all the antiviral medications. 

HIV MEDICATIONS

There are many different types of HIV medications that exist:

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ENTRY INHIBITORS

The mechanism of these medications is to stop viral entry into the cells. 

Examples include: Maraviroc (attachment), Enfuvirtide (penetration). 

INTEGRASE INHIBITORS

The mechanism of these medications is to inhibit HIV genome integration int the host cell. This is done by irreversibly inhibiting HIV integrase

Examples (end in “tegravir”) include: Raltegravir, Elvitegravir, Dolutegravir 

REVERSE TRANSCRIPTASE INHBITIROS (NRTIs)

The mechanism of these medications is to competitively inhibit nucleotide binding to reverse transcriptase and terminate the DNA chain that is being synthesized (because they lack a 3’OH group, making the addition of further nucleotides impossible). Need to be phosphorylated to be active

Examples include: Abacavir, Didanosine, Emtricitabine, Lamivudine, Stavudine, Tenofovir, Zidovudine (ZDV, formerly AZT)

REVERSE TRANSCRIPTASE INHBITIROS (NNRTIs)

The mechanism of these medications is to bind to reverse transcriptase (at a different site then NRTIs). Do not require phosphorylation to be active.

Examples include: Delavirdine, Efavirenz, Nevirapine 

PROTEASE INHIBITIROS  

The mechanism of these medications is to inhibit the HIV-1 protease which cleaves the polypeptide product of the HIV mRNA. This cleavage is required for the proper maturation of the virus. 

Examples include (end in “tavir”): Atazanavir, Darunavir, Fosamprenavir, Indinavir, Lopinavir, Ritonavir, Saquinavir 

OTHER ANTIVIRAL MEDICATIONS

 

NAME  

The mechanism of these medications is to

Examples include: