This page organizes all the antiviral medications.
There are many different types of HIV medications that exist:
The mechanism of these medications is to stop viral entry into the cells.
Examples include: Maraviroc (attachment), Enfuvirtide (penetration).
The mechanism of these medications is to inhibit HIV genome integration int the host cell. This is done by irreversibly inhibiting HIV integrase.
Examples (end in “tegravir”) include: Raltegravir, Elvitegravir, Dolutegravir
REVERSE TRANSCRIPTASE INHBITIROS (NRTIs)
The mechanism of these medications is to competitively inhibit nucleotide binding to reverse transcriptase and terminate the DNA chain that is being synthesized (because they lack a 3’OH group, making the addition of further nucleotides impossible). Need to be phosphorylated to be active.
Examples include: Abacavir, Didanosine, Emtricitabine, Lamivudine, Stavudine, Tenofovir, Zidovudine (ZDV, formerly AZT)
REVERSE TRANSCRIPTASE INHBITIROS (NNRTIs)
The mechanism of these medications is to bind to reverse transcriptase (at a different site then NRTIs). Do not require phosphorylation to be active.
Examples include: Delavirdine, Efavirenz, Nevirapine
The mechanism of these medications is to inhibit the HIV-1 protease which cleaves the polypeptide product of the HIV mRNA. This cleavage is required for the proper maturation of the virus.
Examples include (end in “tavir”): Atazanavir, Darunavir, Fosamprenavir, Indinavir, Lopinavir, Ritonavir, Saquinavir
OTHER ANTIVIRAL MEDICATIONS
The mechanism of these medications is to