Methamphetamine Intoxication

WHAT IS IT?

Methamphetamine intoxication refers to the overdose of amphetamines.

Amphetamines, featured in the popular TV show "Breaking Bad" are responsible for this condition (source)
Amphetamines, featured in the popular TV show “Breaking Bad” are responsible for this condition (source)
WHAT CAUSES IT?

Excessive intake of methamphetamines is responsible for this condition.

WHY IS IT A PROBLEM?

Amphetamines will result in increased norepinephrine concentrations in the synaptic cleft, leading to symptoms of increased norepinephrine signaling in patients taking amphetamines.

WHAT MAKES US SUSPECT IT?

Risk factors

Pas history of amphetamine usage.

Initial Presentation

  • Paranoia 
  • Euphoria 
  • Grandiosity

History Of Present Illness

Tactile hallucinations can be present

Anorexia can be caused by intoxication

Physical Exam Findings

Vital signs (result of adrenergic signaling):

  • Fever
  • Hypertension
  • Tachycardia

HEENT: 

  • Pupillary dilation
CLINICAL WORKUP

Urine drug screen can be used to detect the presence of amphetamines in the patient.

WHAT ELSE ARE WE WORRIED ABOUT?

Cardiac arrest can be a serious complication of amphetamine intoxication.

Seizures may also be caused by this condition.

HOW DO WE TREAT IT? 

Benzodiazepines are used for agitation and seizures.

 

Page Updated: 08.10.2016