The goal of this page is to take the landmark CATIE paper titled “Effectiveness Of Antipsychotic Drugs In Patients With Chronic Schizophrenia” (Lieberman et al. 2005, The New England Journal Of Medicine) and distill down its major takeaways for clinical practice.
WHAT IS THE POINT OF THIS STUDY?
This study is quite simply trying to figure out which second generation antipsychotic is best! There are many options for antipsychotics to choose from, and this paper aimed to try and compare the options to try and demonstrate which option would be best suited for most patients.
WHAT ARE THE MAJOR TAKEAWAYS?
Overall there were a few things that this study highlighted in its results/conclusion.
- The medication that was tolerated for the longest was Olanzapine: this meant that patients stuck to this antipsychotic medicaiotn for the longest amount of time compared to all of the other second generation antipsychotics.
- Olanzapine was associated with the greatest weight gain and increase in measures of glucose/lipid metabolism.
Page Updated: 08.08.2016