Mirtazapine

WHAT IS IT?

Mirtazapine (Remeron) is an α2 selective alpha-blocker. Its action will increase the release of both norepinephrine and serotonin. Other activities of this medication inlcude:

  • Potent 5-HT2 and 5-HT3 receptor antagonist
  • Histamine (H1 receptor) antagonist
WHEN DO WE USE IT?

Depression: this medication belongs to the atypical antidepressant category

Anorexia nervosa: this medication increases appetite, which can be desirable in this context.

Insomnia: this medication can have a sedating effect on patients, which can be useful for those who have difficulty sleeping.

WHEN DO WE AVOID USING IT?

Concomitantly with MAOI medications: too much serotonin signaling can result in serotonin syndrome.

HOW IS IT ADMINISTERED?

Administered orally

Source
Source
WHAT ARE THE SIDE EFFECTS/TOXICITY?

Sedation: this can be desirable in patients with insomnia

Increased serum cholesterol 

Increased appetite that can lead to weight gain. This might be desirable in elderly patients.

FURTHER READING

DynaMed

UpToDate

 

Page Updated: 08.08.2016