WHAT IS IT?
Daptomycin is a lipopeptide antibiotic that depolarizes the cellular membrane by creating transmembrane channels.
WHEN DO WE USE IT?
Gram positive organisms (in the setting of skin infections): Staphylococcus aureus (including MRSA)
WHEN DO WE AVOID USING IT?
Pneumonia: this medication is bound to and inactivated by pulmonary surfactant. For this reason it can not be used to treat pulmonary infections.
HOW IS IT ADMINISTERED?
WHAT ARE THE SIDE EFFECTS/TOXICITY?
Myopathy: that can be associated with creatine kinase (CPK) elevation
ANYTHING ELSE TO KEEP IN MIND?
Inactivated by pulmonary surfactant
Page Updated: 04.25.2017