WHAT IS IT?
Cyclophosphamide is a Alkylating agent that cross links DNA at guanine N-7. It is a nitrogen mustard.
WHEN DO WE USE IT?
- Solid tumor malignancies:
WHEN DO WE AVOID USING IT?
HOW IS IT ADMINISTERED?
WHAT ARE THE SIDE EFFECTS/TOXICITY?
Hemorrhagic cystitis is a series complication of this medication. Prevented with usage of Mesna (thiol group of meson will bind toxic metabolites) or with N-acetylcysteine.
ANYTHING ELSE TO KEEP IN MIND?
This medication requires bioactivation by the liver.
ARCHIVE OF STANDARDIZED EXAM QUESTIONS
This archive compiles standardized exam questions that relate to this topic.
Page Updated: 04.23.2017