WHAT IS IT?
Shigella flexneri is a gram negative rod (bacilli) enteric bacterium.
Non -lactose fermeting
Negative for H2S production on TSI agar
Type II secretion system (“injectosome”): needle like appendage that facilities the direct delivery of toxins to eukaryotic host cell.
Shigella toxin: inactivates 60S ribosome by removing adenine from rRNA. Inhibits protein synthesis and causes cell death.
Human reservoir only
Shigellosis: causes GI mucosal damage that leads to dysentery.
Hemolytic Uremic Syndrome (HUS): the shigella toxin enhances cytokine release, resulting in HUS.
Penicillinase-sensitive penicillins: Amoxicillin, ampicillin; aminopenicillins
OTHER HY FACTS
As few as 10 Shigella organisms can cause disease (depending on the age and condition of the host).
Page Updated: 04.06.2017