Gilbert syndrome is a hereditary liver condition in which the liver does not properly process bilirubin. It is characterized by a pure unconjugated hyperbilirubinemia.
WHAT CAUSES IT?
This is a genetic condition that is caused by autosomal dominant inheritance pattern. Episodes of jaundice are precipitated by periods of stress. Different precipitants of jaundice can include:
- Alcohol consumption
WHAT MAKES US SUSPECT IT?
History Of Present Illness
- Source of stress may precede the presentation of jaundice.
WHAT ARE IMPORTANT FEATURES OF THE PHYSICAL EXAM?
- Signs of jaundice: scleral icterus
CLINICAL WORKUP: SERUM STUDIES
Complete Blood Count:
- Normal hemoglobin/HCT: the jaundice in this condition is NOT caused by hemolysis
Complete Blood Panel (CMP)
- Normal ALT/AST/ALP: all these liver enzymes will be normal because this condition is not characterized by damage to the liver.
- Elevated unconjugated hyperbilirubinemia
- Normal conjugated bilirubin
WHAT IS OUR THRESHOLD FOR DIAGNOSIS?
The following features are “core” to establishing a diagnosis for this condition:
- Unconjugated hyperbilirubinemia
- Normal liver enzymes
- No signs of hemolysis
- No sigs/symptoms of hepatobiliary disease
ARCHIVE OF STANDARDIZED EXAM QUESTIONS
This archive compiles standardized exam questions that relate to this topic.
Page Updated: 01.29.2017