A granulose cell tumor of the ovary is an ovarian tumor that is derived from the ovarian storm (it is a sex cord storm tumor). As the mane suggests it contains a predominance of granulose cells, but also does contain theca cells as well.
WHY IS IT A PROBLEM?
Despite being a malignancy, this tumor type can secrete estrogen which can lead to endometrial hyperplasia/endometrial cancer.
WHAT MAKES US SUSPECT IT?
- Unilateral adnexal mass
- Elevated estrogen
- Precocious puberty (in young children)
- Estrogen: this will be elevated
- Ovarian mass
- Thickened endometrium (if patient has endometrial hyperplasia)
Histology: ganulosa cells are small and cuboidal. They grow in cords/sheets and form follicle or rosetta like structures called Call-Exner bodies. These structures have a gland like appear with a pink eosinophilic enter.
WHAT ELSE ARE WE WORRIED ABOUT?
Endometrial hyperplasia: this tumor type will secrete estrogen which can lead to endometrial hyperplasia.
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Page Updated: 10.29.2016