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WHAT IS IT?
Leuprolide (Lupron) is a GnRH analog that has agonist properties with used in a pulsatile fashion (increases FSH/LH), and antagonistic properties when used continuously. When used continuously it down regulates GnRH receptors in the pituitary, leading to decreased production/release of both FSH/LH. For more on the gonadal hormone axis look here.
WHEN DO WE USE IT?
Pulsatile: Infertility
Continuous: Prostate cancer (adenocarcinoma), uterine fibroids, precocious puberty
WHEN DO WE AVOID USING IT?
Known/suspected pregnancy, breast feeding
HOW IS IT ADMINISTERED?
Intramuscular or sub-cutatneous injection
WHAT ARE THE SIDE EFFECTS/TOXICITY?
Anti-androgen effects, nausea, vomiting
Suggested risk of diabetes and cardiovascular disease
ANYTHING ELSE TO KEEP IN MIND?
Used in combination with compounds like bicalutamide in prostate cancer
FURTHER READING
Page Updated: 02.23.2016