Page Contents
WHAT IS IT?
Pyridostigmine is a long acting acetylcholinesterase inhibitor that does not penetrate the central nervous system. It indirectly increases acetylcholine signaling by preventing the breakdown of acetylcholine.
WHEN DO WE USE IT?
Myasthenia gravis: given the loss of acetylcholine receptors in this condition, this medication can have some therapeutic benefit.
WHEN DO WE AVOID USING IT?
Patients with COPD, asthma, and peptic ulcers should all be watched closely for exacerbation of their conditions when given cholinomimetic agents.
HOW IS IT ADMINISTERED?
Administered orally or by very slow IV injection.
WHAT ARE THE SIDE EFFECTS/TOXICITY?
Gastrointestinal: nausea, diarrhea, abdominal pain/cramps, flatulence.
FURTHER READING
Page Updated: 08.01.2016