WHAT IS IT?
Prochlorperazine (Compazine) is both a typical antipsychotic and an antiemetic medication. It works by blocking D2 dopamine receptors.
WHEN DO WE USE IT?
Migraines: patients who have a migraine and are experiencing nausea can benefit from this medication.
Schizophrenia: this medication can also be used for psychotic disorders given its mechanism of action.
WHEN DO WE AVOID USING IT?
In the setting of CNS depression this medication should be avoided. Examples of this include:
- Alcohol intoxication
- Barbiturate intoxication
- Opiate intoxication
HOW IS IT ADMINISTERED?
This medication is administered orally, by IM , or IV injection.
WHAT ARE THE SIDE EFFECTS/TOXICITY?
Drug-induced parkinsonism can be caused by this medication (given that it blocks dopamine signaling).
Page Updated: 08.02.2016