This page is dedicated to organizing various examples of standardized exam questions whose topic is Factor V Leiden. While this may seem a odd practice, it is useful to see multiple examples of how Factor V Leiden will be characterized on standardized exams (namely the boards and the shelf exams). This page is not meant to be used as a traditional question bank (as all of the answers will be the same), however seeing the classic “test” characterization for a topic is quite valuable.
KEY CHARACTERISTICS OF THIS CONDITION (ON EXAMS)
When it comes to standardized exams, each topic has its own “code” marked by key buzzwords, lab findings, clues, etc. If you are well versed in this code you will be able to more quickly identify the condition that is being discussed, and get the right answer on the exam you are taking. Below is the “code” for Factor V Leiden.
- Hypercoagulability: can take many forms on exams.
Question # 1
Explanation # 1
Question # 2
Explanation # 2
TESTABLE FACTS ABOUT THIS TOPIC (BEYOND ITS IDENTIFICATION)
Many questions on standardized exams go beyond simply recognizing the underlying topic. Often there are specific testable facts regarding some aspect of the topic’s pathophysiology/management/clinical implications that are commonly asked. Some of these are listed below:
- Exact mutation: G → A DNA point mutation Arg506Gln (this mutation is near the cleavage site)
- Mutated Factor V that is resistant to degradation by activated protein C
- Deep vein thrombosis
- Cerebral vein thromboses
- Recurrent pregnancy loss
Page Updated: 05.06.2017