Page Contents
WHAT IS IT?
Trazodone is a serotonin modulator and a medication that has the following activity:
- Blocks 5-HT2 receptors
- Blocks α1-adrenergic receptors
- Blocks histamine H1 receptors
- Weakly inhibits seretonin re-uptake
WHEN DO WE USE IT?
Insomnia: this medication has a strong sedating effect.
Depression: this medication is not a very effective anti-depressant, and needs to be used at a high dosage to help treat depression.
WHEN DO WE AVOID USING IT?
In overly sedated patients: if patients are already being sedated with other medications, other options may need to be considered.
HOW IS IT ADMINISTERED?
Oral administration (after a meal/snack)
WHAT ARE THE SIDE EFFECTS/TOXICITY?
Sedation: this medication is strongly sedating.
Priapism: this is a rare, but possible side effect of using this medication (it can be a urological emergency).
FURTHER READING
Page Updated: 08.08.2016