This page covers topics that relate to the citric acid cycle
EFFECT OF ETHANOL ON THE CYCLE
The metabolism of ethanol by alcohol dehydrogenase and aldehyde dehydrogenase consumes NAD+ and produces NADH (increasing the NADH to NAD+ ratio). This skewed ration inhibits all pathways that require NAD+ (so the entire citric acid cycle is inhibited).
- Ethanol is eventually processed into Acetyl CoA
EFFECT OF THIAMINE DEFICIENCY ON THE CYCLE
There are two important enzymes in the cycle that rely upon thiamine (and will not function in their absence). As a result, this citric acid cycle can not occur without thiamine.
- Pyruvate dehydrogenase: this creates acetyl CoA out of pyruvate
- Alpha-ketoglutarate dehydrogenase complex: this creates sucinnyl-CoA out of alpha ketoglutarate. It consumes NAD+ and creates CO2 and NADH.
Page Updated: 04.30.2017