Fructose Metabolism


This page is dedicate to fructose metabolism. 


Basic metabolic steps:

  1. Sucrose is broken down into glucose and fructose 
  2. Fructose is converted to fructose-1-phosphate by fructokinase 
    1. Deficiency of fructokinase causes essential fructosuria (benign because of hexokinase taking over fructose metabolism)
    2. Hexokinase can turn fructose into fructose 6-phosphate and it will be metabolized in the glucose pathway. 
  3.  Fructose-1-phosphate is metabolized into 2 different products by aldolase B. A deficiency of aldolase B causes hereditary fructose intolerance (serious condition)
    1. DHAP:
    2. Glyceraldehyde: this can be turned into pyruvate eventually (couple more steps). 


Page Updated: 04.29.2017