Pegvisomant

WHAT IS IT?

Pegvisomant is a growth hormone (GH) receptor antagonist. The usage of this medication will inhibit GH signaling  and will produce a rapid decrease in serum IGF-I and other growth hormone-responsive serum proteins (such as IGFBP-3)

WHEN DO WE USE IT? 

Acromegaly/gigantism

WHEN DO WE AVOID USING IT?

When there is known hypersensitivity to this medication.

HOW IS IT ADMINISTERED?

This medication is administered sub-cutaneously.

Source
Source
WHAT ARE THE SIDE EFFECTS/TOXICITY?

Hepatic effects (abnormal liver function tests), back pain, chest pain, diarrhea, dizziness

ANYTHING ELSE TO KEEP IN MIND?

It is not known if this medication is distributed in the milk.

FURTHER READING

DynaMed

UpToDate

Page Updated: 02.16.2016