Page Contents
WHAT IS IT?
Rifampin is a rifamycin, and is a RNA polymerase inhibitor. It inhibits DNA-dependent RNA polymerase in prokaryotes.
WHEN DO WE USE IT?
During active tuberculosis infection: this medication is used to fight against infection with Mycobacterium tuberculosis.
Leprosy: rifampin and dapsone are used together to try and treat the tuberculoid form of leprosy (Mycoplasma leprae). It delays the resistance to dapsone when used for leprosy.
Meningococcal prophylaxis: given to patients with exposure to Neisseria meningitidis in order to prevent infection.
Haemophilus influenzae type B prophylaxis
WHEN DO WE AVOID USING IT?
HOW IS IT ADMINISTERED?
WHAT ARE THE SIDE EFFECTS/TOXICITY?
Drug induced hepatitis can be caused by this medication.
ANYTHING ELSE TO KEEP IN MIND?
Drug resistance: Some mutations can reduce drug binding to RNA polymerase. Monotherapy rapidly leads to drug resistance.
Page Updated: 02.21.2017